Paget Disease Treatment: Your Practical Guide

When dealing with Paget disease, a chronic disorder that disrupts normal bone remodeling, causing bone enlargement and weakening. Also known as osteitis deformans, it can affect any bone but most often hits the skull, spine, and pelvis. Understanding the condition helps you pick the right care path.

One of the core ways to control the disease is with bisphosphonates, medicines that slow down the excessive bone turnover by inhibiting osteoclast activity. These drugs form the backbone of modern therapy because they directly address the abnormal bone remodeling that Paget disease treatment targets. Another option is calcitonin, a hormone that helps reduce bone loss and can be used when bisphosphonates aren’t suitable. Both agents are often combined with calcium and vitamin D supplements to keep the mineral balance in check.

When Surgery Enters the Picture

In cases where the bone has deformed significantly or is causing nerve compression, orthopedic surgery, procedures like joint replacement or decompression, can restore function and relieve pain. Surgical intervention influences disease outcomes by correcting structural problems that medication alone can’t fix. After surgery, patients usually stay on bisphosphonates to prevent the disease from flaring up again.

Beyond the main therapies, pain management, physiotherapy, and regular monitoring of alkaline phosphatase levels form the supportive layer of care. Keeping an eye on lab results tells you whether the treatment is slowing the disease down. Altogether, these approaches—medication, supplements, surgery, and monitoring—create a comprehensive plan that tackles Paget disease from every angle.

Below you’ll find a curated set of articles that dive deeper into each of these treatment pillars, share real‑world tips, and answer common questions. Whether you’re just starting to learn about the condition or looking for the latest management strategies, the resources ahead will give you clear, actionable insight.